Adverse events following mass ivermectin therapy for onchocerciasis

Abstract
The Achi community of south-east Nigeria was given mass ivermectin therapy to control endemic onchocerciasis. 7556 subjects (75·6% of those eligible) were dosed. 992 patients (13·1%) complained of adverse effects, mostly within one week of dosing. Adverse events were mainly of the Mazzotti type. Exacerbation of pruritus (71·2%), oedema (47·4%), headache (46·4%), and worsening of rash (24·4%) were the most common. In 962 subjects (97%), adverse events were mild and did not prevent work. Two patients suffered severe sustained postural hypotension. The incidence of adverse events was greater in villages with a high load of microfilarial infection.