Primary Biliary Cirrhosis Showing a High Titer of Autoantibody

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Abstract
DESPITE the recognition of various cholangiolitic syndromes, uncertainty exists regarding the pathogenesis of chronic diseases of the intrahepatic biliary system. A cholangiolar obstructive syndrome, or "intrahepatic cholestasis,"1 may be caused by certain drugs and chemicals (such as arsphenamine, testosterone and chlorpromazine); cholangiolitic hepatitis, in which intrahepatic biliary obstruction predominates, is a well recognized variant of acute infectious hepatitis. Primary (xanthomatous or intrahepatic) biliary cirrhosis is a chronic condition very rarely preceded by exposure to any agent such as a virus or drug known to cause cholangiolar obstruction; "cholangiolitic cirrhosis" is avoided as an alternate term because its original use by . . .