Acne: Androgens and microbiology
- 1 January 1988
- journal article
- research article
- Published by Wiley in Drug Development Research
- Vol. 13 (2-3) , 157-168
- https://doi.org/10.1002/ddr.430130208
Abstract
Acne, the most prevalent disease of the skin, is a multifactorial follicular disorder in which androgens and microbiology are essential for the occurrence of the pathogenic events that characterize it. The role of the androgen is to stimulate the development and secretory activity of the sebaceous gland, which performs several important actions in the etiopathogenesis of acne. The anaerobic diphtheroid Propionibacterium acnes, a resident organism in acne‐susceptible follicles, is directly responsible for much of the inflammation in acne. This review deals with a description of these events and the therapeutic modalities that have been developed in an attempt to counteract them.Keywords
This publication has 79 references indexed in Scilit:
- Use of cyproterone acetate (CPA) in the treatment of acne, hirsutism and virilismPublished by Elsevier ,2003
- Acne vulgarisJournal of the American Academy of Dermatology, 1987
- Tissue production of androgens in women with acnePublished by Elsevier ,1985
- Acne and hyperandrogenism: Impact of lowering androgen levels with glucocorticoid treatmentJournal of the American Academy of Dermatology, 1984
- Acne and hyperandrogenismJournal of the American Academy of Dermatology, 1984
- In vivo suppression of neutrophil chemotaxis by systemically and topically administered tetracyclineJournal of the American Academy of Dermatology, 1983
- Sustainable rates of sebum secretion in acne patients and matched normal control subjectsJournal of the American Academy of Dermatology, 1983
- Benzoyl peroxide: Percutaneous penetration and metabolic dispositionJournal of the American Academy of Dermatology, 1981
- Topical erythromycin solution in acneJournal of the American Academy of Dermatology, 1980
- Age-Related Changes In The Resident Bacterial Flora Of The Human FaceJournal of Investigative Dermatology, 1975