Searching for SNPs with cloud computing
Top Cited Papers
Open Access
- 20 November 2009
- journal article
- software
- Published by Springer Nature in Genome Biology
- Vol. 10 (11) , 1-10
- https://doi.org/10.1186/gb-2009-10-11-r134
Abstract
As DNA sequencing outpaces improvements in computer speed, there is a critical need to accelerate tasks like alignment and SNP calling. Crossbow is a cloud-computing software tool that combines the aligner Bowtie and the SNP caller SOAPsnp. Executing in parallel using Hadoop, Crossbow analyzes data comprising 38-fold coverage of the human genome in three hours using a 320-CPU cluster rented from a cloud computing service for about $85. Crossbow is available from http://bowtie-bio.sourceforge.net/crossbow/.Keywords
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