Proteins containing the UBA domain are able to bind to multi-ubiquitin chains
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- 13 September 2001
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 3 (10) , 939-943
- https://doi.org/10.1038/ncb1001-939
Abstract
The UBA domain is a motif found in a variety of proteins, some of which are associated with the ubiquitin–proteasome system1,2. We describe the isolation of a fission-yeast gene, mud1+, which encodes a UBA domain containing protein that is able to bind multi-ubiquitin chains. We show that the UBA domain is responsible for this activity. Two other proteins containing this motif, the fission-yeast homologues of Rad23 and Dsk2, are also shown to bind multi-ubiquitin chains via their UBA domains. These two proteins are implicated, along with the fission-yeast Pus1(S5a/Rpn10) subunit of the 26 S proteasome, in the recognition and turnover of substrates by this proteolytic complex.Keywords
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