THE EXCRETION AND DISTRIBUTION OF I131FOLLOWING ADMINISTRATION OF PHYSIOLOGIC AMOUNTS OF LABELED IODIDE, DIIODOTYROSINE AND THYROXINE IN THE RAT1

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Abstract
PRIOR to the availability of radioactive iodine, the metabolism of iodide, diiodotyrosine and thyroxine had been studied extensively in man and animals, and the pertinent literature has been excellently summarized in the monographs of Salter (1940) and Elmer (1938). These early studies were necessarily conducted by the administration of large amounts of the substances concerned in order that their fate could be followed by chemical determination of iodine. Doubt has always existed, therefore, as to whether the results so obtained with large amounts of material were characteristic also of the endogenous metabolism of these compounds. With the availability of I131, similar studies have been repeated in animals on a number of occasions. Several authors have listed data showing the distribution, fate and excretion of iodide in the rat (Leblond, 1942; Permian, Chaikoff and Morton, 1941 and Stevens, Stewart, Quinlin and Meinken, 1949). Gross and Leblond (1947) have studied the distribution of radiothyroxine at two and twenty-four hours following administration.