Anabolic steroids and osteoporosis

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Abstract
Although the pathogenesis of osteoporosis, the most common of the diseases that affect bone, is not fully understood and as a consequence no universally accepted treatment is available, there is at present indirect and direct evidence to show that anabolic agents play a role both in the pathophysiology of the disease and in the curative treatment. Osteoporosis, clinically defined as the loss of bone (osteopenia) sufficient to result in fractures with minimal trauma, generally of the spine, but also of the hip and wrist, does not affect everyone in the older age groups. One out of 4 women will develop osteoporosis after the menopause. Although men and women lose bone mass when they age (Garn et al. 1967; Dequeker 1972), women are more prone to osteoporosis than men. This may be because of hormonal factors and because women have a smaller, more fragile skeleton to begin with. Indirect evidence for

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