Large granular lymphocyte/natural killer cell proliferative disease: Clinical and laboratory heterogeneity

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Abstract
6 patients with a chronic, clinically heterogeneous proliferative disorder of the large granular lyphocytes (LGL) were investigated. In each case the majority of peripheral blood lymphocytes reacted with HNK‐1, OKT3 and T11 monoclonal antibodies, whereas morphology and other immunological features varied from case to case. 2 cases were of particular interest. 1 patient had an expansion of HNK‐1 stained, large agranular rather than granular lymphocytes; another patient's LGL simultaneously expressed NHK‐1, OKT4 and T8 antigens. The heterogeneous features of these abnormally expanded cell populations are similar to those of the normal cell subsets from which they are likely to have originated.

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