Effects of age and sex on microsomal heme oxygenase and cytochrome P-450 content in liver of rats.

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Abstract
Effects of age and sex on microsomal heme oxygenase activity and cytochrome P-450 content were investigated in Wistar rats. Heme oxygenase activity declined with an increase in age: its activity in 100 day old (young) rats was 58% in male and 72% in female rats as compared with respective 30 day old (immature) rats, and in 300 day old (old) rats it was 32% in male and 39% in female rats. In male rats, cytochrome P-450 content based on 100 g body wt decreased only in old rats as compared with immature rats; however, a significant reduction was observed in female rats in the content based on mg microsomal protein, and based on 100 g body wt in young and old animals. In littermate rats at the age of 56 days which were obtained by inbreeding, sex difference was apparent in heme oxygenase activity and cytochrome P-450 content and, further, a good reciprocal correlation between that activity and content (r = -0.9730 in male, and r = -0.8252 in female) was observed.

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