METHOXYFLURANE AND RENAL FUNCTION

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Abstract
The results of a prospective study comparing renal function after anaesthesia using methoxyflurane, halothane or phenoperidine indicate that the use of methoxyflurane is associated with a significant rise in serum uric acid, probably caused by transient distal tubular dysfunction. Reasons are presented to suggest that the rise in serum uric acid is related to urinary fluoride derived from the breakdown of methoxyflurane, and that the changes can be reduced to a degree which renders them clinically unimportant with the rational use of methoxyflurane as a supplement in relaxant techniques. Other tests of renal function and renal handling of water and electrolytes show no significant differences between the groups.

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