Effect of chronic bupivacaine infusion on seizure threshold to bupivacaine

1 July 1987

journal article
research article
Published by Wiley in Acta Anaesthesiologica Scandinavica

Vol. 31 (5) , 423-425
https://doi.org/10.1111/j.1399-6576.1987.tb02595.x

Abstract

Thirty rats were pretreated with a continuous infusion of bupivacaine or placebo. On the fourth day the acute seizure threshold to bupivacaine was determined for both groups. The seizure dose, blood and brain concentration of bupivacaine showed no difference between the groups. The tachyphylaxis seen clinically when bupivacaine is used for a regional nerve blockade does not seem to evolve for the CNS-effects.

Keywords

This publication has 14 references indexed in Scilit:

Etidocaine, Bupivacaine, and Lidocaine Seizure Thresholds in Monkeys
Anesthesiology, 1975
EVALUATION OF THE TOXICITY OF LOCAL ANAESTHETIC AGENTS IN MAN
British Journal of Anaesthesia, 1975
Systemic Absorption of Mepivacaine in Commonly Used Regional Block Procedures
Anesthesiology, 1972
Mechanism of Convulsions Elicited by Local Anesthetic Agents
Anesthesia & Analgesia, 1970
The Role of pH in the Development of Tachyphylaxis to Local Anesthetic Agents
Anesthesiology, 1968
Effect of carbon dioxide on the cortical seizure threshold to lidocaine
Experimental Neurology, 1967
Effects of Lidocaine on the Central Nervous System
Anesthesiology, 1967
Blocking of Cortical Inhibitory Synapses by Intravenous Lidocaine
Nature, 1966
THE USE OF PROLONGED CONTINUOUS SPINAL ANESTHESIA TO RELIEVE VASOSPASM AND PAIN IN PERIPHERAL EMBOLISM
Anesthesiology, 1948