Naloxone Suppresses the Vasodepressor Action of Captopril in the Anaesthetized Dog
- 1 January 1984
- journal article
- research article
- Published by Taylor & Francis in Clinical and Experimental Hypertension. Part A: Theory and Practice
- Vol. 6 (10-11) , 1825-1828
- https://doi.org/10.3109/10641968409046085
Abstract
The effects of intracisternal injection of captopril (0.3 mg/kg) on the systolic pressor response elicited by afferent stimulation of the vagus were investigated in the anaesthetized dog. The captopril-induced decrease in the systolic pressor response to vagal stimulation was reversed by a subsequent injection of naloxone (0.1 mg/kg i.v.). These results suggest the involvement of central opioid mechanisms in the hypotensive properties of captopril.Keywords
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