Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy
- 7 February 1997
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 275 (5301) , 838-841
- https://doi.org/10.1126/science.275.5301.838
Abstract
Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6-hydroxydopamine (6-OHDA) injected into the striatum. Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.Keywords
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