Vasopressin in the Rat with Partial Nephrectomy-salt Hypertension

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Abstract
The role of vasopressin in the pathogenesis of partial nephrectomy (PN)-salt hypertension was examined in the rat. Hypertension was produced by reducing renal mass 70% and substituting 1% saline for drinking water 2-4 days after surgery. PN alone resulted in an increase in systolic blood pressure. Subsequent salt loading led to a further large increase in arterial pressure. On the 2nd-3rd day after substitution of saline for drinking water, urinary vasopressin excretion (UADHV) was increased 6-fold and the plasma vasopressin concentration was increased 2 1/2-fold. UADHV then fell to a level that was 3-fold greater than control values 5 days later. Although there was a marked stimulation of vasopressin release during the period of salt loading, a vasopressin pressor antagonist had only a small effect on arterial pressure. Vasopressin apparently is not a major pressor agent in PN-salt hypertension.