Experimental myositis in rats. I. Histological and creatine phosphokinase changes, and passive transfer to normal syngeneic rats.

  • 1 May 1974
    • journal article
    • Vol. 17  (1) , 139-50
Abstract
An allergic myositis was produced in an inbred strain of rats by giving repeated injections of heterologous muscle with complete Freund's adjuvant. Histological lesions developed after two or more injections. The activity in the serum of the enzyme creatine phosphokinase (CPK) was found to be elevated after two injections and reached maximum levels after three to six injections.