Hadamard Transform Capillary Electrophoresis
- 22 October 1999
- journal article
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 71 (23) , 5444-5446
- https://doi.org/10.1021/ac990625j
Abstract
This paper reports the first demonstration of a multiplex sample injection technique in capillary electrophoresis. The sample was injected into a capillary (effective length, 4 cm) as a pseudorandam Hadamard sequence by a photodegradation technique using a high-power gating laser, and the fluorescence signal, which was measured using a probe excitation beam, was decoded by an inverse Hadamard transformation. The signal-to-noise ratio was improved by a factor of 8, which was in good agreement with the theoretically predicted value of 8.02. This approach is potentially useful for the enhancement of the sensitivity by 3 orders of magnitude in high-resolution capillary electrophoresis, combined with fluorescence detection.Keywords
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