Nortriptyline-Induced Fulminant Hepatic Failure
- 1 January 1995
- journal article
- case report
- Published by Wolters Kluwer Health in Journal of Clinical Gastroenterology
- Vol. 20 (1) , 54-56
- https://doi.org/10.1097/00004836-199501000-00014
Abstract
We describe, to our knowledge, the first reported case of nortriptyline-induced fulminant hepatic failure. This tricyclic antidepressant drug was taken by a postmenopausal woman for 64 days before her presentation. The absence of fever, rash, or marked eosinophilia, the predominant zone 3 necrosis with bridging, and the latent period favor a metabolic idiosyncratic reaction. The fatal outcome underscores the importance of recognizing the association and discontinuing the offending agent.Keywords
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