Effects of Increasing Frequency of Contraction on the Force Velocity Relation of Left Ventricle

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Abstract
The effects of increasing the frequency of contraction on the mechanics of left ventricular contraction were studied in nine canine preparations in which filling pressure was controlled. Increasing the contraction rate produced significant increases in maximum contractile element velocity and maximum wall tension in isovolumic beats, and this augmentation of contraction was evident despite an abbreviation of systole.