Optic neuritis: Local synthesis in the central nervous system of oligoclonal antibodies to measles, mumps, rubella, and herpes simplex viruses

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Abstract
Antibodies [Ab] to measles, mumps, rubella and herpes simplex type 1 viruses in serum and CSF of 10 patients with acute monosymptomatic optic neuritis were characterized by imprint electro-immunofixation (IEIF). Comparisons of the IEIF Ab patterns in serum and CSF indicated that a local synthesis in the CNS of oligoclonal virus Ab took place in 5 of the 10 patients. Of the 5 patients, 3 had a local synthesis of Ab to more than 1 type of virus. Oligoclonal Ig[immunoglobulin]G was detected by agarose electrophoresis of the CSF in 4 of the 5 patients with a local synthesis of virus Ab. There was no association between the locally synthesized Ab and the oligoclonal CSF IgG, indicating that they account for only a minor fraction of the locally synthesized IgG in these patients. In the 5th patient, distinct fractions of locally synthesized virus-specific oligoclonal Ig were detected by the IEIF method, although the agarose electrophoresis showed a normal pattern of CSF IgG.

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