Platinum and palladium derivatives for chemotherapy studies

1 May 1979

journal article
research article
Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry

Vol. 22 (5) , 575-577
https://doi.org/10.1021/jm00191a022

Abstract

Analogs of cis-dichlorodiammineplatinum(II) were prepared in which substituted pyridines (A), 1-(4-aminobenzylidene)indene (B) or DL-3,5,3''5''-tetraoxo-1,2-dipiperazinopropane (ICRF-159) was used in place of ammonia, and in some cases Pt(IV) or Pd(II) was used in place of the Pt(II). Both Pt complexes with ICRF-159 were active against mouse leukemia 1210, but none of the others produced significant life extension following a single i.p. dose of 400 mg/kg. Attempts to prepare complexes of ICRF-159 with Zn(II), Mn(II) and Cr(III) were unsuccessful, but there were indications of complex formation with CuCl2 and with NiCl2.

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