Synthesis (in ent-form) of a novel jalcaguaianolide from Ferula arrigonii Bocchieri
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 13,p. 1651-1652
- https://doi.org/10.1039/p19940001651
Abstract
A recently isolated isodehydrocostus lactone from the genus Ferula(Umbelliferae) has been stereoselectively prepared in ent-form from α-santonin by photochemical transformation to O-acetylisophotosantonic lactone followed by functional group manipulations that conclude with a one-step γ-butyrolactone →Δα,β-butenolide conversion; the synthesis corroborates both the structure and the relative and absolute stereochemistry that have been proposed for the natural product.Keywords
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