Hepatic allograft rejection is associated with increased levels of soluble intercellular adhesion molecule-1
- 1 September 1995
- journal article
- research article
- Published by Wiley in Liver Transplantation and Surgery
- Vol. 1 (5) , 290-295
- https://doi.org/10.1002/lt.500010504
Abstract
Intercellular adhesion molecule‐1 (ICAM‐1) is an adhesion molecule from the immunoglobulin super family that is recognized to be an important factor in the multistep process of cell transendothelial migration and lymphocyte adhesion during antigen recognition and effector cytolysis, mechanisms known to be involved in the pathogenesis of hepatic allograft rejection. A soluble form of ICAM‐1 (sICAM‐1) can be shed into the circulation. In this study, we examined the levels of sICAM‐1 in hepatic allograft recipients as possible markers of cellular rejection and the presence of cytomegalovirus (CMV) hepatitis. We studied three groups of patients, including eight patients with histologically documented cellular rejection, five patients with histologically documented CMV hepatitis, and a liver transplantation control population. Serum samples were obtained at the following times: baseline (1 to 3 days after transplantation), at time of diagnosis of cellular rejection, and at time of diagnosis of CMV hepatitis and 1 week after treatment of rejection episodes. The levels of sICAM‐1 were measured using an established commercial enzyme immunoassay with a sensitivity of 0.3 ng/mL. We found that serum levels of sICAM‐1 were significantly increased in liver transplant recipients who were experiencing hepatic allograft rejection but were unchanged in patients with CMV hepatitis or the time‐matched liver transplant controls. Serum levels of sICAM‐1 decreased significantly after successful treatment of the rejection episode with bolus corticosteroid therapy. We conclude that serum levels of sICAM‐1 may be useful in monitoring the occurrence of rejection and the response to antirejection therapy in liver transplant recipients.Keywords
This publication has 22 references indexed in Scilit:
- Soluble T lymphocyte markers in the diagnosis of cellular rejection and cytomegalovirus hepatitis in liver transplant recipientsJournal of Hepatology, 1994
- Cell adhesion in the immune systemImmunology Today, 1993
- A PHASE I TRIAL OF IMMUNOSUPPRESSION WITH ANTIIC AM-1 (CD54) mAb IN RENAL ALLOGRAFT RECIPIENTSTransplantation, 1993
- ALLOANTIGEN-DEPENDENT ENDOTHELIAL PHENOTYPE AND LYMPHOKINE mRNA EXPRESSION IN REJECTING MURINE CARDIAC ALLOGRAFTSTransplantation, 1993
- DISTRIBUTION OF CELL ADHESION MOLECULES (ICAM-1, VCAM-1, ELAM-1) IN RENAL TISSUE DURING ALLOGRAFT REJECTIONTransplantation, 1993
- VARIATION IN EXPRESSION OF ENDOTHELIAL ADHESION MOLECULES IN PRETRANSPLANT AND TRANSPLANTED KIDNEYS-CORRELATION WITH INTRAGRAFT EVENTSTransplantation, 1993
- DETECTION OF CIRCULATING INTERCELLULAR ADHESION MOLECULE-1 AFTER LIVER TRANSPLANTATION-EVIDENCE OF LOCAL RELEASE WITHIN THE LIVER DURING GRAFT REJECTIONTransplantation, 1993
- RAPID INDUCTION OF INTERCELLULAR ADHESION MOLECULE-1 ON MONOCYTES AND MYELOMONOCYTIC CELL LINES AFTER INTERFERON GAMMA TREATMENTTransplantation, 1992
- Renal allograft rejection: induction and function of adhesion molecules on cultured epithelial cellsClinical and Experimental Immunology, 1992
- Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.The Journal of cell biology, 1988