Reticulo-Endothelial Blockade in Experimental Chagas' Disease

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Abstract
The intravenous injection of colloidal thorium dioxide into mice on 5 consecutive days, 4 of them preceding the day of infection, resulted in a lowered resistance to infection with the "Corpus Christi" strain of T. cruzi. This was reflected by higher infection rates, higher parasitemias, longer patencies, and greater mortality in the mice given the reticulo-endothelial blocking agent than were observed in control animals without blockade. The intraperitoneal injection of trypan blue into mice on the 15th day of infection with the "Brasil" strain of T. cruzi resulted in a temporary drop in parasitemia which may be viewed as a result of reticulo-endothelial stimulation rather than as a chemotherapeutic effect.

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