Determination of Ionized Calcium in Serum by Use of an Ion-Selective Electrode
Open Access
- 1 February 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 18 (2) , 155-160
- https://doi.org/10.1093/clinchem/18.2.155
Abstract
Ionized calcium was determined in serum from 84 normal individuals by using a flow-through calcium-selective electrode operated at 37°C. The mean value was 1.08 ± 0.06 (2 SD) mmol/liter. The relationship of serum ionized calcium concentration to other serum constituents was examined. The effects of hyperventilation and food ingestion on ionized calcium were studied. Respiratory alkalosis, induced by hyperventilation, caused a decrease in ionized calcium of 0.05 ± 0.02 (2 SD) mmol/liter per 0.1 unit increase in pH. In contrast, the metabolic alkalosis induced by food ingestion caused a decrease in ionized calcium of 0105 ± 0.025 (2 SD) mmol/liter per 0.1 unit increase in pH.Keywords
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