A novel non-peptide endothelin antagonist isolated from bayberry, Myrica cerifera
- 22 June 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 305 (1) , 41-44
- https://doi.org/10.1016/0014-5793(92)80651-v
Abstract
A potent non-peptide ET receptor antagonist, myrireron caffeoyl ester (50–235), was isolated from the bayberry, Myrica cerifera. This compound selectively antagonized specific binding of [125I]ET-1, but not of [125I]ET-3, to rat cardiac membranes, ET-1-induced increase in the intracellular free calcium concentration in Swiss 3T3 fibroblasts, and ET-1-induced contraction of rat aortic strips. Thus, 50–235 is the first non-peptide ETA receptor antagonist. This compound can be useful for studying the physiological role of endothelin and exploring its role in various diseases.Keywords
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