The load and distribution of β-amyloid in brain tissue of patients with Alzheimer's disease
- 1 February 2001
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 103 (2) , 88-92
- https://doi.org/10.1034/j.1600-0404.2001.103002088.x
Abstract
Recent findings have underlined the significance of β‐amyloid protein (βA4) in the etiology of Alzheimer's disease (AD). In 60 patients with AD, the amount of βA4 deposition, estimated applying immunohistochemical techniques, was shown to be significantly influenced by apolipoprotein E (ApoE) genotype (ε4/ε4>ε4/x>x/x), by the age at onset (presenile>senile), by the age at death (younger>older patients) and by the duration of the disease (long>short). Morphometric analysis revealed that the βA4 load was highest in the superficial layer of the cortex and a significant influence on the vertical distribution was seen in females but not in males, in familial but not in sporadic cases and in senile but not in presenile cases. Our findings indicate that not only the load but also the vertical distribution of βA4 within cortex is influenced by risk factors such as ApoE genotype and gender.Keywords
This publication has 27 references indexed in Scilit:
- Genetic factors in Alzheimer's disease: A review of recent advancesAnnals of Neurology, 1996
- Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's diseaseAnnals of Neurology, 1996
- Is Early-Onset Alzheimer Disease a Distinct Subgroup Within the Alzheimer Disease Population?Alzheimer Disease & Associated Disorders, 1995
- Alzheimer's disease and soluble AβNeurobiology of Aging, 1994
- Alzheimer's Disease, ß-Amyloidosis, and AgingReviews in the Neurosciences, 1994
- Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.Proceedings of the National Academy of Sciences, 1993
- Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset FamiliesScience, 1993
- Differential pattern of β‐amyloid protein deposition within cortical sulci and gyri in Alzheimer's diseaseNeuropathology and Applied Neurobiology, 1993
- βA4 protein deposition in familial Alzheimer's disease with the mutation in codon 717 of the βA4 amyloid precursor protein gene and sporadic Alzheimer's diseaseNeuroscience Letters, 1993
- Quantifying the pattern of β/A4 amyloid protein distribution in Alzheimer's disease by image analysisNeuropathology and Applied Neurobiology, 1992