Gentamicin-resistant bacillary infection. Clinical features and amikacin therapy

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Abstract
Infections caused by gentamicin sulfate-resistant Pseudomonas aeruginosa and Serratia marcescens occurred in multiple areas in hospitals and caused serious clinical illness and death. Isolates of Pseudomonas organisms were sensitive to some alternative drugs including colistin sulfate, but isolates of Serratia organisms were often resistant to all commercially available parenteral antimicrobials. All isolates were inhibited by amikacin sulfate and 95% were killed by concentrations achievable in serum with recommended doses. Patients (20) with hospital-acquired infections, including 10 with septicemia, were treated with amikacin. Of the 20 patients, [18] had a good clinical and bacteriologic response. Ototoxicity and nephrotoxicity each occurred in 1 patient.

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