The effect of aneuploidy on meiotic crossing over and segregation in yeast

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Abstract
SUMMARY: Meiotic chromosome associations in homothallic strains of S. cerevisiae were investigated by analysis of meiotic spore colonies and crossing over in +/+/− trisomics. The segregants of these aneuploids produce phenotypically distinguishable tetrasomic spore colonies. The data indicate that trivalent associations occur with a high frequency in trisomics of chromosome XVII and that the frequency of second division segregation is markedly increased over that found in the normal dipoid.

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