Serotonergic Agonists and Antagonists Affect Endurance Performance in the Rat
- 1 August 1993
- journal article
- Published by Georg Thieme Verlag KG in International Journal of Sports Medicine
- Vol. 14 (06) , 330-333
- https://doi.org/10.1055/s-2007-1021187
Abstract
The purpose of this experiment was to examine the effects of administration of serotonergic (5-HT) agonist and antagonist drugs on run-time to exhaustion (RUN-EXH) in male and female rats. RUN-EXH was reduced (p-1i.p.) administered immediately prior to exercise (treadmill running at 20 m · min-1 and 5% grade). Conversely, RUN-EXH was increased (p1c and 5-HT2 antagonist) (1.5mg·kg-1i.p.). Drug effects were similar in male and female rats. The negative effects of QD administration on RUN-EXH were not attenuated by administration of the peripherally restricted antagonist, xylamidine tosylate (up to 200ug·kg-1i.p.). The results of this investigation indicated that fatigue during prolonged exercise can be influenced by direct pharmacological administration of a serotonergic agonist and antagonist and that the mechanisms underlying these effects are likely to be central (brain) in nature.Keywords
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