The self renewal probability of hemopoietic stem cells
- 1 December 1968
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 72 (3) , 221-228
- https://doi.org/10.1002/jcp.1040720309
Abstract
The probability of a colony which originated as a single stem cell to become extinct due to differentiation of all of its stem cells in any generation is closely connected to stem cell self renewal probability p. p can be determined from the coefficient of variation of the colony numbers received by reinjecting single colonies of the same age. Whole spleens containing a known average colony number can also be used with advantage for this purpose. The results of both procedures indicate a stem cell self renewal probability p =0.62 ± 0.04, which does not change significantly between the sixth and the fourteenth day of colony development, and an extinction probability ω = 0.63 ± 0.12.Keywords
This publication has 5 references indexed in Scilit:
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- Hemopoietic spleen colony studiesDevelopmental Biology, 1967
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