PHARMACOKINETIC AND TASTE EVALUATION OF IBUPROFEN (MOTRIN) 800-MG TABLETS IN EXTEMPORANEOUS SOLUTION

  • 1 February 1988
    • journal article
    • research article
    • Vol. 15  (2) , 345-347
Abstract
A 4-way crossover study was done to determine the pharmacokinetic and palatability characteristics of ibuprofen 800 mg tablets when given as a solution in various beverages. When compared to the tablet itself, no significant difference was noted for any variable measured for an orange juice solution. A delay in time-to-peak concentration (Tmax) was noted for a dilute cherry syrup solution. Changes in Tmax, peak concentration achieved and area-under-the-curve were noted with a Coca-Cola solution. The authors conclude Coca-Cola to be clearly inappropriate for this method, a dilute cherry syrup solution slightly better and orange juice to be the preferred option.

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