HIGH-DENSITY LIPOPROTEIN CHANGES DURING TREATMENT OF DIABETIC-KETOACIDOSIS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 11  (2) , 102-105
Abstract
Serum concentration of apoprotein A, high density lipoprotein (HDL)-cholesterol and HDL-cholesterol and HDL-phospholipids was studied in 13 consecutive episodes of diabetic ketoacidosis. In 3 patients with type I diabetes mellitus HDL2 and HDL3 subfractions were also measured. Patients with type I diabetes showed greatly decreased HDL-cholesterol concentration on admission which increased into the normal range after insulin treatment, while HDL-phospholipids decreased during treatment and apoprotein A remained almost unmodified. In 3 patients with type I diabetes a virtual absence of HDL2-cholesterol subfraction was observed, which rose to normal values during recovery. Conversely, in type II diabetes mellitus HDL-cholesterol was slightly reduced on administration, and tended to decrease during recovery. The existence of abnormalities in the quantitative composition of HDL was implied; HDL-cholesterol apparently can fluctuate much more rapidly than previously thought.