On the Type of Hemoglobin in the Neoplastic Cell of Virus-Induced Fowl Erythroleukemia2

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Abstract
The virus-induced fowl erythroleukemic cell may contain as much as one third of the hemoglohin content in the normal fowl erythrocyte (about 10 and 30 picograms of hemoglobin per cell, respectively). The hemoglobin prepared from erythroleukemic cells has been analyzed by paper- and starch-bloc electrophoresis and also with its alkali-denaturation kinetics. Erythrocyte hemoglobin preparations from normal birds and from the remaining normal erythrocytes in leukemic birds served as comparison material. The normal erythrocytes from both normal and leukemic birds showed two distinct hemoglobin components, I and II, of which component II accounts for 20 to 40 percent of the total. Hemoglobin prepared from erythroleukemic cells showed the same two types and in the same proportions as those of the normal erythrocyte hemoglobin. This indicated that the hemoglobin synthesis during the neoplastic cell development induced by the leukemia virus was under a similar genetic control as during the normal red-cell development.

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