VITAMIN B12 AND FOLIC ACID CONCENTRATIONS OF HUMAN LIVER WITH REFERENCE TO THE ASSAY OF NEEDLE BIOPSY MATERIAL
- 1 February 1961
- journal article
- Published by Wiley in Immunology & Cell Biology
- Vol. 39 (1) , 1-8
- https://doi.org/10.1038/icb.1961.1
Abstract
SUMMARY: Vitamin B12 and folic acid concentrations in samples of human liver have been assayed microbiologically. The yield of both vitamins is increased by papain digestion of liver homogenates. The vitamin B12 concentrations of ten normal livers ranged from 0·61 μg./gm. to 1·02 μg./gm. wet tissue; the folic acid concentrations of the same livers ranged from 0·69 μg./gm. to 1·60 μg./gm. wet tissue.Material aspirated from the liver by suction needle biopsy was satisfactory for the assay of vitamin B12 and folic acid provided that the specimen weighed at least 7 mg.Methods are described for the processing and assay of needle biopsy material.Keywords
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