Specific interactions of liposomes with PMN leukocytes upon incorporating tuftsin in their bilayers
Open Access
- 3 December 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 178 (1) , 109-113
- https://doi.org/10.1016/0014-5793(84)81251-x
Abstract
Incorporation of tuftsin derivatives, Thr‐Lys‐Pro‐Arg‐NH‐C18H37 or Thr‐Lys‐Pro‐Arg‐NH‐(CH2)2‐NH‐COC15H31, into an egg phosphatidylcholine/cholesterol liposome bilayer led to significantly enhanced binding of the liposomes to PMN leukocytes at 37°C but not at 0°C. Under identical conditions, no such enhanced binding of the liposomes was observed with erythrocytes and lymphocytes. These results demon‐strate that grafting of tuftsin on the liposome bilayer enables the liposome to recognize specifically the PMN leukocytes and to deliver its contents to these cells.Keywords
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