Immunocytochemical evidence for anti‐LHRH and anti‐ACTH activity in the “F” antiserum

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Abstract
An antiserum which has previously been thought to be specific for LHRH‐ like immunoreactive material was shown to contain two populations of antibodies, one demonstrating anti‐LHRH activity and the other anti ‐ACTH (1‐24) activity. In rat and mouse, ACTH(1‐4)‐like immunoreactive substance is present in perikarya within the basal hypothalamus and in fibers in arcuate, periventricular and dorsomedial nuclei. LHRH‐like immunoreactivity is present in fibers within the median eminence and arcuate nucleus, in a few fibers running along the ventral border of the hypothalamus, and in a small number of cell bodies within the medial basal hypothalamus.