Long-Term Follow-Up of the Changes in Circulating Cytokines, Soluble Cytokine Receptors, and White Blood Cell Subset Counts in Patients with Rheumatoid Arthritis (RA) After Monoclonal Anti-TNFα Antibody Therapy
- 1 January 1999
- journal article
- clinical trial
- Published by Springer Nature in Journal of Clinical Immunology
- Vol. 19 (5) , 305-313
- https://doi.org/10.1023/a:1020543625282
Abstract
To investigate the mechanism of the long-lasting efficacy of chimeric monoclonal anti-TNFα antibody (cA2) therapy for rheumatoid arthritis (RA), eight patients with refractory RA were treated with a...Keywords
This publication has 42 references indexed in Scilit:
- THE THERAPEUTIC EFFECTS OF AN ENGINEERED HUMAN ANTI-TUMOUR NECROSIS FACTOR ALPHA ANTIBODY (CDP571) IN RHEUMATOID ARTHRITISRheumatology, 1995
- Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseasesImmunology Today, 1995
- Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.Journal of Clinical Investigation, 1994
- Construction and initial characterization of a mouse-human chimeric anti-TNF antibodyMolecular Immunology, 1993
- Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development.The Journal of Experimental Medicine, 1992
- The importance of the t cell in initiating and maintaining the chronic synovitis of rheumatoid arthritisArthritis & Rheumatism, 1992
- Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical SamplesImmunological Reviews, 1992
- Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritidesArthritis & Rheumatism, 1988
- Augmented interleukin‐1 production and hla–dr expression in the synovium of rheumatoid arthritis patientsArthritis & Rheumatism, 1988
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988