Screening of antifungal antibiotics according to activities inducing morphological abnormalities.

1 January 1983

journal article
Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry

Vol. 47 (9) , 2061-2069
https://doi.org/10.1271/bbb1961.47.2061

Abstract

Activities of various known antifungal antibiotics known to induce morphological abnormalities of fungi and yeasts were examined. The observations seemed to provide a standard for detecting new antifungal antibiotics with a selective mode of action. Three new antibiotics, AC549, ATS1287 (leptomycin) and AM630 (fosfazinomycin), were found according to their activities to induce characteristic morphological changes of test organisms. AC549 seemed to be a compound related to gougeroxymycin.

Keywords

MODE OF ACTION
YEASTS
MORPHOLOGICAL
ABNORMALITIES
ANTIFUNGAL ANTIBIOTICS
GOUGEROXYMYCIN
ATS1287
ACTIVITIES TO INDUCE

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