Modification of Toxicity of Violamycin BI (VBI) by Complex Formation with DNA, Metal Ions, and by Pretreatment with α-Tocopherol

Publisher Website
Google Scholar
Abstract
In connection with studies on lowering the toxicity of violamycin BI (VBI) the intravenous (i.v.) LD50 values were determined in mice for VBI, VBI complexed with DNA, Fe3+ or Pt2+, and after pretreatment with α-tocopherol. The results indicate that the toxicity of VBI is reduced by complex formation with DNA or ferric ions including a partial decrease of the antimicrobial and antiviral activity.