Partial Reversibility of Airflow Limitation and Increased Exhaled NO and Sputum Eosinophilia in Chronic Obstructive Pulmonary Disease
- 1 November 2000
- journal article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 162 (5) , 1773-1777
- https://doi.org/10.1164/ajrccm.162.5.9910112
Abstract
We investigated the relationship between the reversibility of airflow limitation, the concentration of nitric oxide (NO) in exhaled air, and the inflammatory cells in the sputum of patients with stable chronic obstructive pulmonary disease (COPD). We examined nine normal healthy control subjects and 20 nonatopic patients with COPD. Ten patients had no reversibility of airflow limitation (increase in FEV(1) of < 12% and < 200 ml after 200 microg of inhaled salbutamol), and 10 patients had partial reversibility of airflow limitation (increase in FEV(1) of < 12% but > 200 ml after 200 microg of inhaled salbutamol). Exhaled NO levels were higher in COPD patients with partial reversibility of airflow limitation than in those with no reversibility of airflow limitation (median 24 [interquartile range 15.3 to 32] ppb versus 8.9 [4.6 to 14.7] ppb; p < 0.01). Compared with healthy control subjects, only COPD patients with partial reversibility of airflow limitation had increased concentrations of sputum eosinophils. We conclude that, in patients with stable COPD, even a partial bronchodilator response to inhaled salbutamol is associated with increased exhaled NO and sputum eosinophilia, suggesting that these patients may have a different response to treatment than do those without reversible airflow limitation.Keywords
This publication has 30 references indexed in Scilit:
- Effect of inhaled steroids on airway hyperresponsiveness, sputum eosinophils, and exhaled nitric oxide levels in patients with asthmaThorax, 1999
- The cellular composition of induced sputum in chronic obstructive pulmonary diseaseEuropean Respiratory Journal, 1999
- Increased production of endogenous nitric oxide in patients with bronchial asthma and chronic obstructive pulmonary diseaseClinical and Experimental Allergy, 1998
- Nitric oxide measured with single-breath and tidal-breathing methods in asthma and COPDEuropean Respiratory Journal, 1998
- Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma.Thorax, 1998
- Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task ForceEuropean Respiratory Journal, 1997
- Nitric oxide from the human respiratory tract efficiently quantified by standardized single breath measurementsActa Physiologica Scandinavica, 1997
- Exhaled nitric oxide: a new lung function test.Thorax, 1996
- Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task ForceEuropean Respiratory Journal, 1995
- Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary diseaseJournal of Allergy and Clinical Immunology, 1993