CHEMISTRY OF TC-99M TRACERS .2. INVITRO CONVERSION OF TAGGED HEDP AND PYROPHOSPHATE (BONE-SEEKERS) INTO GLUCONATE (RENAL AGENT) - EFFECTS OF CA AND FE(II) ON INVIVO DISTRIBUTION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 17  (3) , 208-211
Abstract
Sodium gluconate transforms the boneseekers 99mTc-HEDP [technetium-99m (1-hydroxyethylidene) diphosphonate] and 99mTc-pyrophosphate into the renal agent 99mTc-gluconate. In these in vitro processes, pyrophosphate is displaced faster than HEDP, while the HEDP reaction is accelerated by Ca2+. The in vivo distributions in the rat of these bone and kidney agents are altered by the prior local injection of Ca or Fe(II). These transformation and translocation phenomena are explained in terms of the mechanistic behavior of Tc(IV) complexes.

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