The Electrolytic Resistance of the Blood Clot in Thrombocytopenia: And its Relationship to the Platelet Concentration

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Abstract
In thrombocytopenia either hypersplenic or secondary to disease of the bone marrow, there is a marked reduction in the electrolytic resistance of the blood clot. Following splenectomy (in hypersplenism) there is a prompt and sharp rise in the resistance to normal. The platelet count also returned to normal. The percentage clot vol. is inversely related to the clot resistance. After splenectomy the large clot volume shrinks to normal. These findings are not related to the level of the platelet count in the blood stream. The resistance appears to be a function of the degree of clot retraction. It is not related to the platelet count. Hence, it appears likely that clot retraction is affected by factors other than the number of platelets in the blood stream.
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