Application of genetic algorithms to the construction of exact D-optimal designs

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Abstract
This paper studies the application of genetic algorithms to the construction of exact D-optimal experimental designs. The concept of genetic algorithms is introduced in the general context of the problem of finding optimal designs. The algorithm is then applied specifically to finding exact D-optimal designs for three different types of model. The performance of genetic algorithms is compared with that of the modified Fedorov algorithm in terms of computing time and relative efficiency. Finally, potential applications of genetic algorithms to other optimality criteria and to other types of model are discussed, along with some open problems for possible future research.