Inter-relationship among individual vitamin K-dependent clotting factors at different levels of anticoagulation.
Open Access
- 1 November 1987
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 24 (5) , 621-625
- https://doi.org/10.1111/j.1365-2125.1987.tb03221.x
Abstract
1. The effect of subtherapeutic doses of warfarin on the activities of the four vitamin K-dependent clotting factors was studied at steady state in five patients each of whom had completed a therapeutic course of anticoagulation. 2. The four clotting factor activities were shown to be depressed to a similar extent for a given dose of warfarin. 3. The prothrombin complex activity was significantly lower than that of any of the clotting factors.This publication has 17 references indexed in Scilit:
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