ORGANO-PHOSPHATE PESTICIDE DICHLORVOS-INDUCED INCREASE IN THE RATE OF LIPID-PEROXIDATION IN THE DIFFERENT REGIONS OF THE RAT-BRAIN - SUPPORTING ULTRASTRUCTURAL FINDINGS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 2  (1) , 43-52
Abstract
Commonly used organophosphate pesticide [insecticide] dichlorvos is known to cause neurologic lesions but exact mechanism is unclear. Using dose-dependent inhibition of acetylcholinesterase activity as an index of neurotoxicity, effects of 3 doses of dichlorvos (0.6, 1.5 and 3.0 mg/kg body wt i.p. daily for 10 days) were observed on rate of lipid-peroxidation in cerebrum, cerebellum and brain stem of albino rats. EM study of dichlorvos-intoxicated rat cerebellum was also carried out. Dose-dependent increase in rate of lipid peroxidation was found in all brain regions and increased incidence of lipofuscin-like pigment granules was discernible in Purkinje cells of cerebellar cortex.