Identification of genetic markers forMycobacterium pinnipediithrough genome analysis
Open Access
- 1 July 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 248 (2) , 147-152
- https://doi.org/10.1016/j.femsle.2005.05.034
Abstract
Tuberculosis in seals is caused by Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex. In this study, we evaluated the extent of genetic variability among Mycobacterium bovis and M. pinnipedii by microarray-based comparative genomics. We identified two deletions that are exclusive to M. pinnipedii: PiD1 that removes the orthologues of the M. tuberculosis genes Rv3530c and Rv3531c, and PiD2 that encompasses genes Rv1977 and Rv1978. Interestingly, a deletion overlapping the previously described RD2 region was identified in some isolates of Mycobacterium microti and further characterised.Keywords
This publication has 14 references indexed in Scilit:
- Microarray analysis of Mycobacterium microti reveals deletion of genes encoding PE-PPE proteins and ESAT-6 family antigensTuberculosis, 2004
- Tuberculosis in seals caused by a novel member of the Mycobacterium tuberculosis complex: Mycobacterium pinnipedii sp. nov.International Journal of Systematic and Evolutionary Microbiology, 2003
- A new evolutionary scenario for the Mycobacterium tuberculosis complexProceedings of the National Academy of Sciences, 2002
- Tuberculosis in a Wild Subantarctic Fur Seal from ArgentinaJournal of Wildlife Diseases, 1999
- Molecular characterization of mycobacteria isolated from sealsMicrobiology, 1999
- Tuberculosis in sea lions and fur seals from the south-western Atlantic coastRevue Scientifique et Technique de l'OIE, 1996
- Genetic characterization of mycobacteria from South American wild sealsVeterinary Microbiology, 1995
- Tuberculosis in wild seals and characterisation of the seal bacillusAustralian Veterinary Journal, 1993
- Seals, Seal Trainers, and Mycobacterial InfectionAmerican Review of Respiratory Disease, 1993
- TUBERCULOSIS IN A CAPTIVE COLONY OF PINNIPEDSJournal of Wildlife Diseases, 1991