Symptomatic Gallstones – a Disease of Non-Smokers?

Abstract
Most patients with symptomatic gallstones undergo cholecystectomy. Since smoking may influence gallstone formation by depressing postaglandin synthesis and mucus production in the gallbladder, we have examined smoking habits in a group of cholecystectomy patients. Two hundred and forty seven of 400 patients (62 %) responded to a comprehensive postal questionnaire with ‘buddy’ controls of the same age and sex. Patients and controls did not differ significantly in their age, weight, past medical history, drug usage or alcohol consumption. Female patients had had a mean of 2.4 (SD 1.8) pregnancies, female controls 2.0 (SD 1.5; p 2 = 14.4, 1 d.f.p

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