Release of Anti‐HIV Mediators after Administration of Leukotriene B4to Humans

Publisher Website
Google Scholar
Abstract
Background. CD8+ T cells can control human immunodeficiency virus (HIV) through the lysis of infected cells and the release of soluble mediators, such as macrophage inflammatory protein (MIP)-1β, which prevent entry of HIV and/or inhibit HIV replication. Because neutrophils represent a major source of α-defensins and, to a lesser extent, MIP-1β, we determined whether leukotriene B4 (LTB4), a potent neutrophil agonist, would trigger the release of these 2 anti-HIV peptides.

This publication has 0 references indexed in Scilit: