Biosynthetic origin of the 2,2-dimethylchromen ring: formation of deguelin by a cyclase enzyme from Tephrosia vogellii

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Abstract
An enzyme from Tephrosia vogellii which converts rot-2′-enonic acid into the 6′,6′-dimethylchromen deguelin has been isolated and purified; the 5′-hydroxy-6′,6′-dimethyl compound is not an intermediate, nor has an intermediate been observed.