Assessment of nonsteroidal anti-inflammatory drug combinations by the polyurethane sponge implantation model in the rat.
Open Access
- 1 August 1983
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 42 (4) , 439-442
- https://doi.org/10.1136/ard.42.4.439
Abstract
The anti-inflammatory effect of single doses and combinations of aspirin and commonly used nonsteroidal anti-inflammatory drugs was investigated by the polyurethane sponge implantation model of acute inflammation. Dose response curves were performed to delineate a suppressive (high) and nonsuppressive (low) dose of each drug prior to studying these doses in combination with aspirin. The results suggest that a combination of aspirin in either high or low dose does not increase the anti-inflammatory effect of other nonsteroidal anti-inflammatory drugs in this model of inflammation.This publication has 14 references indexed in Scilit:
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